Integrated Skin Care
Ageless bodies. Beautiful skin.

Ageless Bodies.  Beautiful Skin.



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Manual Mechanism of action 20.04.2009 1 of 1
Although the mechanism of action with the Dermaroller is not totally explored, nevertheless the results for the improvement
of skin structure and scars, especially acne scars, in over 100 000 cases speak a clear language. The procedure
with the Dermaroller became standard expressions in scientific literature with the terms COLLAGENINDUCTION-
THERAPY (short: CIT) and MICRONEEDLING. Our present state of knowledge is the following: A
drum shaped roller stud with 192 fine micro-needles from 0.5 to 1.5 mm in length and 0.1 mm in diameter penetrate
to dermis repeatedly for about 20 times. The skin cells react to these micro injuries and stimulation with the release
of various growth factors.
These in return stimulate the proliferation of undifferentiated cells and this reproduction results in NEOCOLLAGENESIS
and NEO-ANGIOGENESIS. New tissue structures are generated in forms of elastin- and collagen
fibers as well as new capillaries. They integrate into the existing upper dermal layer without any fibrotic traces.
New fibroblasts and capillaries will migrate through the punctured scar tissue. Both processes result in new tissue
formation to “fill” the former atrophic scar and new capillaries result in a significant better blood supply that in return
results in an improved re-pigmentation.
So far we regarded the mechanism of action of the Dermaroller for skin improvement, especially for atrophic scars,
from a more isolated aspect of the Neo-Collagenesis, and therefore the aspect of the Neo-Angiogenesis for scar repigmentation
was considered too narrowly. There is enough evidence that both disfigurements can be successfully
treated. In comparison to skin texture improvement the rectification of scars is easier to judge by the physician, patient
and subtle objective observers. According to the reports and scientific findings and clinical cases we received
from experts worldwide the rate of success for the treatment of atrophic scars is 70 to 80% after 2 to 4 procedures.
As explained further down, it is my point of view that the cell biological activities in the skin during and after Dermarolling
are far more complex as assumed till today. The wound healing mechanisms after an injury are well reName
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searched and do not require any further explanations. Although numerous needles with a diameter of 0.1 mm penetrate
the dermis and sub-dermis repeatedly the same tissue spot (about 15 to 20 times) down to a depth of maximum
1,5 mm, no wounds in the classical sense at set, and traces of fibrotic tissue could not be detected in histological examination.
(A tiny, but solid needle should not be mixed up with a hollow injection needle. Injection needles have
always an inclined cut, and will therefore act as a cutting device, that usually results in a scar).
The tiny micro-bleedings after Dermarolling originate from punctured capillaries that are “emptied” and noted as
tiny petechiae in the skin’s surface. But the needles do not cause bleeding in the classical sense. If the micro bleeding
sets free sufficient various growth factors to induce cell-proliferation is doubtful and requires more research. But
if we replace the term injury after a needle prick with the term sensation we get a totally different picture of cellbiological
sequence in the skin. But before we have a closer look at the reactions of various skin cells by signals, we
would like to shed some light on the skin improvements after Dermarolling:
Facts after one or several Dermaroller sessions:
a) Significant improvement of wrinkles and skin texture
b) The skin looks fresher and more juvenile
c) Scars and acne scars are drastically reduced
d) Pigment spots become more even or disappear in total
After a Dermaroller therapy we always observe the same reactions: NEO-COLLAGENESIS and NEOANGIOGENESIS.
Up to what extent other cell formations are stimulated for regeneration is subject to further research. But at this point
we definitely can make the statement that the Dermaroller definitely contributes to skin rejuvenation. Neo-
Angiogenesis connotes a better blood flow. The supply with more oxygen and nutrition is increased, and the evacuation
of metabolism debris is accelerated.
At this point we also would like to emphasize the fact that from our point of view no ablative procedure will stimulate
Neo-Angiogenesis, and that includes also fractional lasers. We believe it is the opposite since the “hot” laser
beam “fuses” the capillaries and other tissue, and stimuli for sprouting of new vessels will be suppressed. The laser
beam transforms protein into necrosis (>50°C) that finally transforms into fibrotic tissue. These subdermally set fibrotic
points become confluent after several treatments and result rather in an upholstering effect below wrinkles.
But it is more than unlikely that a fractional laser beam stimulates neo-angiogenesis. And additionally to this fact,
the laser beam suppresses bleeding by fusing capillaries, and this in return will stops the release of growth factors
from blood platelets. And in addition the laser beam will destroy stems cells as well as other non-differentiated cells
and obstructs their potential for proliferation.
Pic.5 Till 2005 we knew little about the mechanism of action
of the Dermaroller in respect of neo-collagenesis. But the
findings of Martin Schwarz changed the entire picture, and we
were encouraged to invest more time and financial sources to
analyze this phenomenon. The article of Min Zhao et al. in
NATURE magazine 2006 was the ignition point to invest
more time in the study of cell biology were we found many
To any injury or sensation of the epithelium the organism reacts with electrical signals, and these in return initiate a
cascade of regeneration mechanisms. Usually there is a resting potential of -80 mV between the cells and the surrounding
electrolyte, the extra cellular liquid. The internal cell is charged negative, the surrounding interstitium and
the skin surface is charged positive. Not only after an injury, but obviously already after a stimulation the skin cell
membrane becomes semi-permeable to release various chemical elements such as potassium, sodium and anionic
proteins, as well as growth factors into the interstitium. This process changes the electrolyte, the conductivity increases
and the electrical resistance decreases dramatically. At the same time the electrical charge inside the cell
drops to 0 mV or above to +30 mV. This potential difference is essential for the regenerative process. Research at
Owen Biosciences and MatTek® laboratories show, that the needles of the Dermaroller have their own electrical
potential that obviously increases the electrical potential between the intra- and extra cellular situation. These tests
were performed on laboratory skin that does not have blood vessels. But still an increase of collagen fibers and released
growth factors could be substantiated.
Based on these facts we have revised our articles and graphics about the mechanism of action during and after Dermarolling.
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Pic. 6. This change of the electrical potential was
measured on a nerve cell and takes about 1 millisecond.
Skin cells might have a slightly higher reaction time.
Pic. 7. The left graphic shows the distribution of chemical
elements in cells and the extra-cellular space before an injury
or stimulation. In this stage the membrane is (almost) not
Pi.8. In case of epithelial stimulation nerve cells send signals
within milliseconds to the surrounding skin cells. The
membrane of the skin cells becomes permeable and releases
the chemical properties in delayed steps into the interstitium.
The electrolyte changes its conductivity (diagrammed in a
deeper blue).
Within milliseconds this process is reversed. The membrane
changes its permeability to the opposite and the previous
released chemicals return into the cells. As longs as the
nerve signal persist, this release and return from and back to
the cells continues. This continued process is called ion-pump.
We assume that cell-released growth factors, and possibly
those from punctured capillaries, stimulate stem cells and
other non-differentiated cells to proliferate. Newly produced
fibroblasts migrate towards the point of injury for repair
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Pic. 9. But a „repair“ as in normal injuries does not take
place. Since the needles are sterile and no gaping wound exists,
the fibroblasts are possibly “fooled” by the needles. The
needles penetrate the skin only for fractions of seconds, and
the pricking channels are closed within minutes by skin’s
elasticity. (As shown in in-vitro pictures of the University of
Jena after Dermarolling).
The resting potential is restored and fibroblasts transform
into collagen fibers. Point 5 indicated the neo-angiogenesis of
capillaries (see more distinct graphics further down).
In relation to its seize the cell-membrane potential is enormous.
In average the membrane has a thickness of 70 to 100
nm. If the membrane would be up-scaled to 1 m the electrical
potential difference would be 10 million Volt. (Jaffe et a.)
Histological findings of a blinded study. Performed by Schwarz und Laaff, Freiburg/Germany, 2006. In the right biopsy
an increase of exactly 1000% of new collagen- and elastin fibers (stained purple) could be found.
Pic. 10. Not needled biopsy Pic. 11. Needles biopsy after 6 weeks.
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Pic. 12. There are a lot of discussions “how long” a needle for collagen induction should be.
The slide with the projected needle clearly indicates that new collagen formation only forms in the upper dermis and
down to an average depth of 0.5 to 0.6 mm.
There is no logic reason to use longer needles when the average skin thickness is only 1.5 mm.
As postulated by Augst et al. the new collagen formation integrates into the elastic collagen grid below the corium
but never forms a fibrotic cluster, as it is the case after wound repair by fibrosis.
Most Dermaroller treatments were performed on acne scars. The sharp needles perforate the stringent and hard scar
tissue. This supports the migrating of new capillaries and collagen fibers into the previous scar bed to form new tissue.
Pic.13. Pic.14.
Pics. 15 & 16. Patient after 2nd Dermaroller treatment (healing still in progress). Dermaroller models used: MF8 and
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Pic. 17. Neo-Angiogenesis can only be logically
explained when non-differentiated endothelial
cells proliferate and new capillary sprouts migrate
into the needled fibrotic tissue.
The previous hypo-pigmented scar tissue and its
surrounding resume a normal blood circulation
and the ivory-like scar disappears.
It sure would be a misjudgment to assume that only fibroblasts and endothelial cells would be stimulated by Dermarolling.
This would be in contrary to the phenomenon that skin-needling obviously also simulates other cells to
proliferate or to decrease over production (sebum, melanin, etc.). It was observed in many cases that pigment concentrations
associated with acne scars were evenly distributed after the treatment. The only conclusion we have at
this stage is that electrical signals stimulated by the needling process have a direct influence on all skin cells.
The body reacts to all ablative procedures with its repair mechanism – fibrosis. To Dermarolling the body reacts
with cell regeneration.
No doubt, during the development of the Dermaroller the coincidence acted like Godfather. As little is known about
needling it is was along and frustrating way for the achievement of our today’s knowledge. 1999 we started with the
development of a device for transdermal delivery with tiny and short needles (0.2 mm). Today the Dermaroller is
widely used (>95%) for skin therapies such as scars, pigmentations problems, etc. But in respect of the entire
mechanism of action we still are in need of explanation, but the facts speak a clear language. The therapeutic value
of the Dermaroller is already beyond any doubt, but we are still looking for some missing stones to form the final
mosaic. In 2007 and 2008 many physicians approached us and asked for support for further investigations and studies.
It was our pleasure to comply with their demands. We hope that most articles will be published this in 2008 to
bring us deepened insights for present and new therapies with the Dermaroller.
Therefore we would like to take the opportunity to thank all these scientists. Their commitment is our motivation.
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ONLY stem cells in the vicinity of a distance of 1 to 2 mm
around the point and path of injury receive signals to proliferate.
Therefore we can conclude:
NOT PRESSURE stimulates the amount of new stem cells and
undifferentiated cells but the NUMBER of passes of the
Dermaroller-Needles through the skin.


 2011 Dec;10(4):317-23. doi: 10.1111/j.1473-2165.2011.00583.x.


Combination of microneedling and glycolic acid peels for the treatment of acne scars in dark skin.


Skinfiniti the Aesthetic Skin and Laser Clinic, Navi Mumbai, Maharashtra, India.



  Acne scars can cause emotional and psychosocial disturbance to the patient. Various modalities have been used for the treatment of acne scars like punch excision, subcision, peels, microdermabrasion, unfractionated and fractioned lasers. The latest in the treatment armamentarium is microneedling. Acne scars commonly coexist with postinflammatory hyperpigmentation. A combination of microneedling and glycolic acid (GA) peels was found to give excellent results in the treatment of such scars. The aim was to study the efficacy of a combination of microneedling with glycolic peel for the treatment of acne scars in pigmented skin.


  Thirty patients in the age group of 20-40 years with atrophic box type or rolling scars with postinflammatory hyperpigmentation were chosen for the study. Two groups were made. The first group comprised of 30 patients in whom only microneedling was performed once in 6 weeks for five sessions. In the second group of 30 patients, a combination of microneedling and 35% GA peels was carried out. Patients from both groups were evaluated on the basis of Echelle d'Evaluation clinique des Cicatrices d'acné classification.


  Based on the objective scoring and its statistical analysis, there was significant improvement in superficial and moderately deep scars (grade 1-3). There was also improvement in skin texture, reduction in postacne pigmentation in the second group.


  Microneedling is a simple, inexpensive office procedure with no downtime. It is safe in Indian skin (skin types III-IV). The combined sequential treatment with GA peel caused a significant improvement in the acne scars without increasing morbidity.

© 2011 Wiley Periodicals, Inc.



Microneedling Therapy in Atrophic Facial Scars: An Objective Assessment



Atrophic facial scars are always a challenge to treat, especially the ones that are deep-seated and/or involve much of the face. Microneedling or dermaroller therapy is a new addition to the treatment armamentarium for such scars that offers a simple and reportedly effective management of these scars.


The aim of the present study was to perform an objective evaluation of the efficacy of dermaroller treatment in atrophic facial scars of varying etiology.

Materials and Methods:

Thirty-seven patients of atrophic facial scarring were offered multiple sittings of microneedling (dermaroller) treatment and their scars were evaluated and graded clinically and by serial photography at the start as well as at two months after the conclusion of the treatment protocol. Any change in the grading of scars after the end of treatment and follow-up period was noted down. The patients were also asked to evaluate the effectiveness of the treatment received on a 1-10 point scale. The efficacy of dermaroller treatment was thus assessed both subjectively by the patients as well as objectively by a single observer.


Overall 36 out of the total of 37 patients completed the treatment schedule and were evaluated for its efficacy. Out of these 36 patients, 34 achieved a reduction in the severity of their scarring by one or two grades. More than 80% of patients assessed their treatment as ‘excellent’ on a 10-point scale. No significant adverse effects were noted in any patient.


Microneedling therapy seems to be a simple and effective treatment option for the management of atrophic facial scars.

Keywords: Atrophic scars, microneedling, therapeutic results


Scarring is a particularly distressing phenomenon and is most unwelcome when it occurs on the face. Scars can arise on the face due to a number of causes, the commonest of which is acne vulgaris. Post-acne facial scarring is a psychologically devastating condition and the affected patient invariably suffers from low self-esteem and many other psychological ill-effects because of this condition.[1] Facial scarring has always been a challenge to treat and there are different treatment options for the management of these scars. However, the majority of these treatment options suffer from the limitation of either being marginally effective or else having considerable morbidity. Treatment options like laser resurfacing or dermabrasion that offer significant improvement in facial scars are invariably associated with considerable morbidity and downtime interference with the daily activities of the patient in the post-treatment period.[2,3] On the other hand, treatments like microdermabrasion and non-ablative resurfacing with lasers that are associated with a minimal or no downtime, do not show the same level of efficacy as the traditional, ablative resurfacing techniques.[4,5] New treatments and techniques are being added over the last few years to overcome these limitations.

One such device is dermaroller. Treatment with these hand-held devices is known by many names like microneedling therapy, collagen induction therapy or dermaroller therapy. There are some pathological as well as clinical studies now available in the world literature that have documented a favorable clinical and histopathological response in the skin after dermaroller treatment.[6,7] However, there is a definite paucity of objective clinical trials on the efficacy of dermaroller treatment in facial and other types of scars.

Post-acne facial scars have been classified into many morphological types and the ideal treatment option depends upon the type of scarring. Recently, a clinical grading system has been devised to grade the severity of post-acne facial scars [Table 1]. This grading system, proposed by Goodman and Baron, encompasses all the morphological types of post-acne scars and uses a simple clinical examination as the tool to grade the scars on objective lines.[8] This grading system can also be used to assess the severity of other etiological types of facial scars. The present study is aimed at ascertaining the efficacy of dermaroller treatment objectively in the management of atrophic facial scars.

Table 1
Grading of atrophic scars


The present study was performed on 37 patients suffering from localized or generalized atrophic facial scarring of variable etiology. The patients were photographed and assessed clinically at the time of enrolment to grade the severity of scarring, by a single trained dermatologist as per the grading system proposed by Goodman and Baron. Only patients with Grade 2 to Grade 4 atrophic scarring were enrolled for the study. A history of application of topical retinoids, use of systemic retinoids or any other scar treatment procedure in the previous three months were used as exclusion criteria. Presence of any active infection anywhere, active acne on the face or a keloidal tendency in the patient also served as exclusion criteria. Informed written consent was obtained from all the patients who were enrolled for the study. Microneedling or dermaroller treatment was performed at monthly intervals till a satisfactory outcome was achieved or a maximum of four sittings whichever was earlier. A minimum of three treatment sessions was considered essential for inclusion for assessment. Area of interest was anesthetized using a thick application of topical anesthetic cream (eutectic mixture of prilocaine and lignocaine), about 30-45 min before the procedure. Dermarollers with 1.5mm long needles were used and the endpoint for any treatment session was the presence of uniform bleeding points over the scarred area. In patients with deep-seated scarring, the skin was stretched in a perpendicular direction to the dermaroller movement so that the base of the scars could also be reached. After the end of the treatment regimen, the scars were again assessed and graded by the same trained dermatologist, and the patients were followed up monthly for the next two months. The final assessment and grading of scars was done at the end of two months of follow-up and repeat photographs were then taken. The appearance and grading of scars was then compared with that in the pre-treatment period and any change in the grading of scars was noted. In addition to this objective assessment, the change in the severity or grading of scars was assessed photographically also. On objective lines, an improvement of scarring by two grades or more was labeled as ‘excellent’ response while a ‘good’ response meant an improvement by a single grade only. In those patients where the scar grading remained the same after the completion of treatment irrespective of any visible change in the facial scarring the response was labeled as ‘poor’.

The patients were also given a preformed questionnaire at the end of the follow-up period wherein they were asked to rate the improvement in their scars on a 10-point scale. Rating above 6 was graded as ‘excellent response’, rating between 4 and 6 served as ‘good response’ and rating below 4 meant a ‘poor response’. A subjective assessment of the treatment protocol on the part of the patients was also thus obtained.

Adverse effects that arose as a result of the treatment were also noted down including any adverse effects in the immediate post-treatment period. The patients were specifically asked about the immediate post-treatment sequelae and whether there was any interference with their daily activities in the post-treatment period. Post-procedure, patients were advised topical antibiotic application for two to three days and sun avoidance for at least a week after each dermaroller treatment.


Of the 37 patients, the majority (32) were suffering from post-acne atrophic facial scarring while two patients each had post-traumatic and post-varicella scarring and one patient had post-herpetic scarring. Females (23) predominated over males (14) in the study group. The age of the patients ranged from 13 to 34 years, with the mean age of 22.4 years. The youngest patient was a female aged 13 years who was suffering from severe post-herpetic scarring [Figures ?[Figures11 and ?and2]2] and the oldest patient was a male aged 34 years with severe post-acne scarring. The majority of the patients were however in the third decade of their life.

Figure 1
Post-herpetic scarring before treatment
Figure 2
Post-herpetic scarring post-treatment

All patients tolerated the procedure well and except for a temporary erythema and post-inflammatory hyperpigmentation in one patient, no adverse effects were noted in any patient. No patient reported any interference in his/her daily activities in the immediate post-treatment period and the only change noted in the immediate post-treatment period was a mild crusting that persisted for one or two days. The patients were able to attend their daily duties on the same day or the next day after the dermaroller sitting.

Only one patient dropped out of the study as she could not complete the minimum three sittings required for final assessment The rest of the 36 patients were thus available for evaluation of results at the end of the study period.

Of the 36 patients who filled the questionnaire at the end of the study period, 29 patients reported the response as ‘excellent’ (7-10 on the 10-point scale), four patients reported the response as ‘good’ (score of 4-6) and only three patients reported the response as ‘poor’ (score of <4).

Objective assessment of the patients' scarring at the start of the study revealed Grade 4 scarring in seven patients, Grade 3 scarring in 21 patients and Grade 2 scarring in nine patients. The patient who dropped out of the study was suffering from Grade 4 scarring and therefore we had only six patients from the original Grade 4 scarring group for evaluation at the end of the study period. Of these six patients, only one patient achieved an ‘excellent’ response on objective assessment. In this patient the grading of scars at the end of treatment could be reduced to Grade 2. In three others, the scar grading could be reduced to third grade and thus the response in these patients was labeled as ‘good’. In two patients, no significant change could be observed in the severity of scarring and the response was thus labeled as ‘poor’.

In 21 patients with Grade 3 scarring, an excellent response was similarly noted in 16 patients (reduction to Grade 1 or less), three patients achieved a good response while two patients had a poor response to treatment.

In patients with Grade 2 scars all nine showed an excellent response to treatment.

Thus, overall, 26 out of the total of 36 patients (72.2%) showed an excellent response to dermaroller treatment while six others achieved a good response (16.7%). Only four patients (11.1%) out of the total of 36 failed to show a significant response to treatment [Table 2].

Table 2
Response to dermaroller treatment

Correlating the response rate with the grade of scarring present, an excellent response rate was achieved in the majority of patients with Grade 2 and 3 scarring. However, in patients with Grade 4 scarring, only one out of the six patients had excellent response, while in three others (50%), the response was good. However, because of only a few patients with Grade 4 scars in the present study, the comparative results could not be tested for their statistical significance.

Correlating the response with the morphological type of scarring present, we found a good to excellent response in rolling and boxcar scars while pitted scars showed only moderate improvement. However, contrary to expectations, we could observe a definite improvement in pitted scars and deep boxcar scars as well [Figures ?[Figures33 and ?and4].4]. Deep tunnels and other complicated scars showed a poor response to treatment.

Figure 3
Post-acne scarring before treatment
Figure 4
Post-acne scars after dermaroller treatment

Of the five patients who had scarring from causes other than acne, we observed an excellent response in the single patient of post-herpetic scarring. This patient who had a Grade 3 scarring at the start of treatment [Figure 1] and we were able to reach a stage of Grade 1 scars at the end of treatment [Figure 2]. All the four patients of post-varicella and post-traumatic scarring (two each) showed a ‘good’ response to treatment on objective analysis.


Microneedling therapy, also known as collagen induction therapy, is a recent addition to the treatment armamentarium for managing post-acne scars. The treatment is performed as an office procedure after application of a local anesthetic cream, by means of an instrument known as a dermaroller. A dermaroller is a simple, hand-held instrument consisting of a handle with a cylinder studded all around with fine, stainless steel needles 0.5 to 2 mm in length. This needle-studded cylinder is rolled on the skin in multiple directions to achieve a therapeutic benefit and hence the name ‘dermaroller’. These needles cause small pinpoint injuries on the treated skin, which apparently heal within two to three days with no post-treatment sequelae. Treatment with dermaroller is performed at four to eight week intervals and multiple sittings are needed to achieve the desired effect on the skin. Microneedling or dermaroller treatment is becoming popular all over the world, not only in the management of post-acne scars but also as an anti-aging therapy. There are certain advantages with dermaroller or microneedling therapy over laser resurfacing; former does not lead to any epidermal injury as is seen with lasers, there is minimal downtime associated with the procedure unlike ablative laser resurfacing and the treatment is far cheaper as compared to lasers. The treatment can be performed in an office setting and does not need any extensive special training or expensive instruments.

Choice of treatment of post-acne scars depends both on the morphological type as well as the severity of each scar present on the face.[9,10] Post-acne scars have also been graded into four different grades depending upon the overall severity of the scarring present regardless of the individual morphology of the scars.[8] We have analyzed the efficacy of dermaroller, both in different types of scars and different grades of scars. Excellent response was seen in rolling or boxcar scars, while moderate response was seen in pitted scars. The severity of scars improved by two or more grades in 26 (72.2%) of our patients and in a further six (16.7%) patients we could achieve a reduction in scars by a single grade. Thus, on an overall basis a good to excellent response was achieved in 32 out of 36 patients (88.7%). It was also interesting to note that facial scars due to other etiologies also responded, with good or excellent response. Dermaroller treatment thus has definite advantages such as its cheaper cost, the comparative ease of the overall procedure and also the minimal downtime associated with it. Lack of any significant adverse effects is also an added advantage.

It is also important to emphasize the limitations of dermaroller treatment. Grade 4 scars did not respond as well as Grade 3 and Grade 2 scars. Some types of scars like linear scars or deep pitted scars did not respond well. However, these scars are difficult to treat even by other modalities such as lasers and may need surgical correction.

In summary, dermaroller is a simple, inexpensive office method of treatment for management of facial scars of different etiologies. It represents an important tool in the dermatosurgeon's armamentarium in managing this common and challenging cosmetic problem.



Source of Support: Nil



Conflict of Interest: None declared.



1. Orentreich D, Orentreich N. Acne scar revision update. Dermatol Clin. 1987;5:359–68. [PubMed]
2. Alster TS. Cutaneous resurfacing with CO2 and erbium: YAG lasers: Preoperative, intraoperative and postoperative considerations. Plast Reconstr Surg. 1999;103:619–32. [PubMed]
3. Alster TS, Lupton JR. An overview of cutaneous laser resurfacing. Clin Plast Surg. 2001;28:37–52.[PubMed]
4. Ang P, Barlow RJ. Nonablative laser resurfacing: A systematic review of the literature. Clin Exp Dermatol. 2002;27:630–5. [PubMed]
5. Shim EK, Barnette D, Hughes K, Greenway HT. Microdermabrasion: A clinical and histopathologic study. Dermatol Surg. 2001;27:524–30. [PubMed]
6. Aust MC, Fernandes D, Kolokythas P, Kaplan HM, Vogt PM. Percutaneous collagen induction therapy: An alternative treatment for scars, wrinkles and skin laxity. Plast Reconstr Surg.2008;121:1421–9. [PubMed]
7. Camirand A, Doucet J. Needle dermabrasion. Aesthetic Plast Surg. 1997;21:48–51. [PubMed]
8. Goodman GJ, Baron JA. Postacne scarring: A qualitative global scarring grading system. Dermatol SurgeJ Am Acad Dermatol. 2001;45:109–17.
9. Kadunc BV, Trindade De Almeida AR. Surgical treatment of facial acne scars based on morphological classification; A Brazilian experience. Dermatol Surg. 2003;29:1200–9. [PubMed]

Articles from Journal of Cutaneous and Aesthetic Surgery are provided here courtesy of Medknow Publications



4.1.8. Needling

Skin needling is a recently proposed technique that involves using a sterile roller comprised of a series of fine, sharp needles to puncture the skin. At first, facial skin must be disinfected, then a topical anesthetic is applied, left for 60 minutes. The skin needling procedure is achieved by rolling a performed tool on the cutaneous areas affected by acne scars (Figure 6), backward and forward with some pressure in various directions. The needles penetrate about 1.5 to 2 mm into the dermis. As expected, the skin bleeds for a short time, but that soon stops. The skin develops multiple microbruises in the dermis that initiate the complex cascade of growth factors that finally results in collagen production. Histology shows thickening of skin and a dramatic increase in new collagen and elastin fibers. Results generally start to be seen after about 6 weeks but the full effects can take at least three months to occur and, as the deposition of new collagen takes place slowly, the skin texture will continue to improve over a 12 month period. Clinical results vary between patients, but all patients achieve some improvements (Figures ?(Figures77 and ?and8).8). The number of treatments required varies depending on the individual collagen response, on the condition of the tissue and on the desired results. Most patients require around 3 treatments approximately 4 weeks apart. Skin needling can be safely performed on all skin colours and types: there is a lower risk of postinflammatory hyperpigmentation than other procedures, such as dermabrasion, chemical peelings, and laser resurfacing. Skin needling is contraindicated in the presence of anticoagulant therapies, active skin infections, collagen injections, and other injectable fillers in the previous six months, personal or familiar history of hypertrophic and keloidal scars [].

Figure 6
Needling: the procedure.
Figure 7
Needling: patient before the treatment.
Figure 8
Needling: patient after the treatment.


4.1.9. Combined Therapy

There is a new combination therapy for the treatment of acne scars. The first therapy consists of peeling with trichloroacetic acid, then followed by subcision, the process by which there is separation of the acne scar from the underlying skin and in the end fractional laser irradiation. The efficacy and safety of this method was investigated for the treatment of acne scars. The duration of this therapy is 12 months. Dot peeling and subcision were performed twice 2-3 months apart and fractional laser irradiation was performed every 3-4 weeks. There were no significant complications at the treatment sites. It would appear that triple combination therapy is a safe and very effective combination treatment modality for a variety of atrophic acne scars [].


There are no general guidelines available to optimize acne scar treatment. There are several multiple management options, both medical and surgical, and laser devices are useful in obtaining significant improvement. Further primary research such as randomized controlled trials is needed in order to quantify the benefits and to establish the duration of the effects, the cost-effective ratio of different treatments, and the evaluation of the psychological improvement and the quality of life of these patients.


D 2012 Nov;38(11):1823-8. doi: 10.1111/j.1524-4725.2012.02552.x. Epub 2012 Aug 22.

Treatment of striae distensae using needling therapy: a pilot study.


Department of Dermatology, Chung-Ang University College of Medicine, Chung-Ang University Hospital, 224–1 Heukseok-dong, Dongjak-gu, Seoul, Korea.



Striae distensae are dermal scars characterized by flattening and atrophy of the epidermis. Although many treatment modalities have been attempted with variable results, there is no criterion standard treatment modality for striae distensae.


To evaluate the effectiveness and safety of a disk microneedle therapy system (DTS) in the treatment of striae distensae.


Sixteen Korean volunteers with striae distensae alba or rubra were enrolled. Patients received three treatments using a DTS at 4-week intervals. Clinical response to treatment was assessed by comparing pre- and post-treatment clinical photographs, skin biopsies, and patient satisfaction scores. Clinical improvement was assessed using the quartile grading scale.


Marked to excellent improvement was noted in seven (43.8%) patients, with minimal to moderate improvement in the remaining nine. Patient satisfaction scores showed that six (37.5%) patients were highly satisfied, eight (50.0%) were somewhat satisfied, and two (12.5%) were unsatisfied. There were no significant side effects except mild pain, erythema, and spotty bleeding.


Disk microneedle therapy system (DTS) can be effectively and safely used in the treatment of striae distensae.


 2011 Nov-Dec;9(6):347-51.

Skin needling in the treatment of the aging neck.


Department of Systematic Pathology, Division of Dermatology, University of Naples Federico II, Naples, Italy.


The aim of this study was to estimate the efficacy of skin needling in the treatment of the aging neck. Eight patients with aging necks were included in the study. Each patient was treated with 2 sessions of needling. The evaluation of treatment effectiveness was based on changes from baseline on the Global Aesthetic Improvement Scale, the Wrinkle Severity Rating Scale, photographic and ultrasonographic images, and silicone rubber microrelief impressions of a selected neck region before and after therapy. Analysis of the photographs, the degree of irregularity of the surface microrelief, and the ultrasound images showed that, after 2 sessions, the lesions' severity grade was reduced in almost 90% of the patients. The present study presents evidence for the efficacy of skin needling for the aging neck.

[PubMed - indexed for MEDLINE]

 2011;2011:158241. doi: 10.1155/2011/158241. Epub 2011 Apr 7.

Skin needling to enhance depigmenting serum penetration in the treatment of melasma.


Section of Dermatology, Department of Systematic Pathology, University of Naples Federico, Street Sergio Pansini 5, 80133 Napoli, Italy.


Melasma is a common hypermelanotic disorder affecting the facial area which has a considerable psychological impact on the patient. Managing melasma is a difficult challenge that requires long-term treatment with a number of topical agents, such as rucinol and sophora-alpha. Aims. We aim to compare the combined treatment of skin needling and depigmenting serum with that using depigmenting serum alone in the treatment of melasma, in order to evaluate the use of microneedles as a means to enhance the drug's transdermal penetration. Methods. Twenty patients were treated with combined skin needling and depigmenting serum on one side of the face and with depigmenting serum alone on the other side. The outcome was evaluated periodically for up to two months using the Melasma Area Severity Index score and the Spectrocolorimeter X-Rite 968. Results. The side with combined treatment (skin needling + depigmenting serum) presented a statistically significant reduction in MASI score and luminosity index (L) levels compared to the side treated with depigmenting serum alone, and clinical symptoms were significantly improved. Conclusions. Our study suggests the potential use of combining skin needling with rucinol and sophora-alpha compounds to achieve better results in melasma treatment compared to rucinol and sophora-alpha alone


 2009 Dec;34(8):874-9. doi: 10.1111/j.1365-2230.2009.03291.x. Epub 2009 May 22.

Acne scarring treatment using skin needling.


Department of Systematic Pathology, Division of Clinical Dermatology, University of Naples Federico II, Naples, Italy.



Acne is a common condition seen in up to 80% of people between 11 and 30 years of age and in up to 5% of older adults. In some patients, it can result in permanent scars that are surprisingly difficult to treat. A relatively new treatment, termed skin needling (needle dermabrasion), seems to be appropriate for the treatment of rolling scars in acne.


To confirm the usefulness of skin needling in acne scarring treatment.


The present study was conducted from September 2007 to March 2008 at the Department of Systemic Pathology, University of Naples Federico II and the UOC Dermatology Unit, University of Rome La Sapienza. In total, 32 patients (20 female, 12 male patients; age range 17-45) with acne rolling scars were enrolled. Each patient was treated with a specific tool in two sessions. Using digital cameras, photos of all patients were taken to evaluate scar depth and, in five patients, silicone rubber was used to make a microrelief impression of the scars. The photographic data were analysed by using the sign test statistic (alpha < 0.05) and the data from the cutaneous casts were analysed by fast Fourier transformation (FFT).


Analysis of the patient photographs, supported by the sign test and of the degree of irregularity of the surface microrelief, supported by FFT, showed that, after only two sessions, the severity grade of rolling scars in all patients was greatly reduced and there was an overall aesthetic improvement. No patient showed any visible signs of the procedure or hyperpigmentation.


The present study confirms that skin needling has an immediate effect in improving acne rolling scars and has advantages over other procedures.